Investigating the protective effects of dexamethasone against cisplatin-induced damage in a Spermatogonial Stem Cell (SSC) model assessed using flow cytometry

Could you briefly introduce yourself and your summer research project?

My name is Seema, and I am a Reproductive Biology honours student. This summer I undertook an internship in The Centre For Reproductive Health at the Institute for Regeneration and Repair, Little France. 

Advances in childhood cancer treatment have improved survival, but infertility remains a major side effect. Cisplatin is highly gonadotoxic, damaging spermatogonial stem cells (SSCs) essential for future sperm production. Prepubertal boys, unable to bank sperm, rely on preserving their SSC pool. My summer project aimed to investigate dexamethasone as a potential chemoprotectant against cisplatin-induced spermatogonial damage.

Which funding did you receive for your research, and how did you get it?

I received the Carnegie Vacation Scholarship Fund after submitting an application through their website and presenting them with a project proposal. I attended the Edinburgh Immunology and Infection Summer School where they provided us with lots of useful information regarding funding sources and where to apply.

What was the most rewarding part of your summer research?

The most rewarding part of my internship was knowing I had contributed to the overall cause the Mitchell Lab Group are working towards. It was fulfilling to see how my individual project formed part of a larger research effort, and to recognise that my results could help inform future experiments.

Why should students get involved in a summer research project?

The experience I gained over the summer has been invaluable. I would strongly encourage taking part in a summer research project, as it allows you to build on the wet-lab skills developed in the early years of the course. It can also provide a foundation for your honours dissertation project and better prepare you for the challenges of final year.

How has this research experience influenced your future study and career paths?

Beyond academic development, I benefited from engaging with the scientific community through seminars and lab meetings. These opportunities not only broadened my understanding of the field but also inspired me to consider pursuing a Master’s research degree in the future.

What advice would you give future students applying for summer research scholarships?

Be persistent! Supervisors are often extremely busy, but showing genuine enthusiasm makes a strong impression. Keep emailing and don’t be discouraged by the first rejection – other opportunities will come along. The confidence and experience you gain through this process will make it worthwhile.