Characterising the Synaptic Dysfunction of the Ubiquitin Proteasome System in Fragile X Syndrome

Can you introduce yourself and your summer research project?

Hi, I’m Amelia and I completed my summer research project after finishing my third year of Neuroscience BSc at The University of Edinburgh. My project was based in the Louros Lab, investigating synaptic dysfunction of the ubiquitin proteasome system (responsible for protein degradation) in Fragile X Syndrome (a neurodevelopmental disorder). 

How did you receive the funding for your research project?

I’m grateful to have been funded by the BMTO summer vacation scholarship during my research project, having applied after being unsuccessful for the Gurdon Studentship from the British Society for Developmental Biology. For the BMTO application, I wrote a short paragraph on why I wanted to apply for the scholarship as well as a brief project proposal with support from my supervisor.

What was the most rewarding part of your summer research?

By far the most rewarding part was experiencing the forefront of scientific research, particularly since this was my first time entering a research lab. Moreover, I feel fortunate to have worked with such dedicated, organised, and inspirational colleagues and I wouldn’t have had half the internship experience without the continuous support and mentorship from Susana, Nagore and Linéa. 

Why should students get involved in a summer research project?

A summer internship is a fantastic opportunity to gain invaluable experience prior to starting your Honours project. It definitely provided the confidence boost I needed to go into fourth year and I am proud of how much I have developed as a scientist. I had the opportunity to be trained on new equipment such as the freezing microtome and confocal microscope, and was soon confident enough to carry out experiments on my own. Additionally, presenting in the poster session was a great experience to enhance public speaking and science communication skills.

How has this research experience influenced your future study and career paths?

Completing this internship solidified my ambition to pursue a PhD in neurodevelopmental disorders, with a particular focus in Fragile X Syndrome. I’m excited to continue in this field of research during my Honours project next year.

What advice would you give future students applying for summer research scholarships?

Start early. I started applying for internships before November. Come prepared to meetings with perspective supervisors and do something you're interested in and passionate about otherwise you'll be bored and won't find the value in the experience. Finally, don't be intimidated by supervisors as a lot of them are very nice and are willing to help accommodate internships for you.  

View Amelia Haigh's poster for more information: