Investigation into the effects of sodium valproate on the developing fetal mouse testis in vitro

Can you introduce yourself and your summer research project?

I am Adomas Liugaila, a fourth year Pharmacology Honours student, with a strong interest in Reproductive Biology. My summer project perfectly aligns these two fields – I was investigating the effects of sodium valproate on the developing fetal mouse testis in vitro. Epilepsy is one of the most common neurological disorders in UK with approximately one-third of patients being females of reproductive age. Management of epilepsy is crucial as intense seizures can cause detrimental effects to the fetus. On the contrary, some anti-epileptic drugs can also cause fetal malformation. For example, sodium valproate is an anti-epileptic drug, which has been recently contraindicated to cause teratogenic effects to the developing fetus. Therefore, the aim of the project was to study the impact of sodium valproate administration on the testosterone levels, as well as the morphology and health of cells of the fetal mouse testis in vitro.

How did you receive the funding for your research project?

I received funding from the Society for Reproduction and Fertility (SRF) through their summer vacation scholarship program. My supervisor suggested that I apply, and the application details can be found on the SRF website. 

Vacation Scholarships | Society for Reproduction and Fertility.

What was the most rewarding part of your summer research?

The most rewarding aspect was gaining independence and confidence in the lab by learning various lab techniques. Also, it was invaluable making connections in the Reproductive Toxicology field.

Why should students get involved in a summer research project?

It is a great opportunity to try out different research fields, as well as understand whether academia is right for you. Moreover, I feel much more prepared for the upcoming Honours project by gaining hands-on experience.

How has this research experience influenced your future study and career paths?

I found a field that perfectly aligns Pharmacology and Reproductive Biology. This experience motivated me to pursue my studies further on in this field.

What advice would you give future students applying for summer research scholarships?

There’s no right way to apply – if you are passionate about the field and the topic, that enthusiasm will naturally come through in your application.

View Adomas Liugaila's poster for more information: