The study has opened up new lines of investigations into functional and molecular roles of TRIM25 and other E3 ubiquitin ligases incell biology and control of pathogenic infections. Image The innate immune system is the body's first line of defense against viruses. The tripartite motif containing 25 (TRIM25) is an E3 ubiquitin ligase thought to be a key component in the activation of innate immune response. TRIM25 has recently been identified as an RNA-binding protein, raising the question of whether its RNA-binding activity is important for its role in innate immunity. Here, we review TRIM25's mechanisms and pathways in non-infected and infected cells. This protein represents a large group of proteins with newly identified RNA-binding potential and can serve as an exemplar towards critical evaluation of protein functions in biological systems. Further information Read the online publication in WIREs RNA here Dr Michlewski lab profile Postgraduate programme information in Infection Medicine Publication date 27 Aug, 2020
