Research Projects

Algorithms, software and platform construction for single-cell spatiotemporal genomics big data analysis

DR Wanlu Liu, MOST, National Key R&D Program Young Scientist Project

Mechanism of ELF3 High Expression of Lung Squamous Cell Carcinoma Subgroup Domesticated Neutrophils from Tumor Suppression to Tumor Promotion

Dr Jian Liu, National Natural Science Funds of China - General Project 

Molecular Mechanism of Hypoxia-inducible Factor Proline Hydroxylase Mediated Nutritional Regulation of Development and Senescence in Caenorhabditis elegans

Prof Di Chen, National Natural Science Funds of China - General Project 

Rapid prediction of chondrocyte plasticity and study of key regulatory mechanisms

Dr Yishan Chen, National Natural Science Funds of China - General Project 

Study on the Mechanism of Zfp467 Regulating the Regenerative Potential of Polyploid Hepatocytes

Dr Yinhua Jin, National Natural Science Funds of China - Young Scientists Fund

Microneedle patches loaded with engineered extracellular vesicles promote scar-free healing of skin wounds by regulating fibroblast reprogramming

Dr Jia Dong, National Natural Science Funds of China - Young Scientists Fund

Mechanoresponsive mechanisms regulating cytokinesis under confinement

Dr Chew Ting Gang, National Natural Science Funds of China - RFIS-II 

Comparative biology of a natural, healthy host - bats

Prof Aaron Irving, National Natural Science Funds of China - General Project - RFIS-II 

Deep learning enhanced disease-specific T-cell receptor characterization and functional validation

Prof Wanlu Liu, National Natural Science Funds of China - General Project 

The materials science mechanism of the superior "meniscus-bone" interface tissue and its regeneration

Dr Xiaozhao Wang, National Natural Science Funds of China - General Project 

Understanding mechanisms of Glp1r expressing NTS neurons that control feeding behavior and energy balance

Dr Weiwei Qiu, National Natural Science Funds of China - General Project 

Adipocyte-derived NRG4 regulates the lipogenesis of mammary epithelial cells via ERBB4/STAT5 signaling in lactation

Dr Chaochen Wang, National Natural Science Funds of China - General Project 

New Photocatalytic Eye Hydrogel for Precise Diagnostic and Therapy of Multidrug Resitant Bacterial Keratitis

Dr Min Zhou, National Natural Science Funds of China - General Project 

Construction of human musculoskeletal system multiomics database and its application in arthritis research

Dr Junxin Lin, National Natural Science Funds of China - Young Scientists Fund

The effect and mechanism of in situ integrated microsphere-based scaffolds with orchestrated metallic ion release on the minimally invasive treatment of osteoporotic fractures

Dr Danni Shen, National Natural Science Funds of China - Young Scientists Fund

Regulatory mechanism of RhoA protein mechanical response during mitosis

Dr Chew Ting Gang, National Natural Science Funds of China - General Project   

Mechanism of m6A code reader protein igf2bp1 regulating pluripotency of human embryonic stem cells

Prof Di Chen, National Natural Science Funds of China - General Project   

Role of G protein regulator rgs22 in hemorrhagic hydrocephalus and ciliary homeostasis in neonates

Dr Qianting Zhang, National Natural Science Funds of China - General Project   

Study on lineage transformation of lung cancer by system biology

Dr Zhaoyuan Fang, National Natural Science Funds of China - General Project   

IGFBP5-TCH3 mediated homogenization of stem cells for the treatment of osteoporotic bone defects

Dr Yuan Yuan, National Natural Science Funds of China - General Project   

Study on the role of proteasome in mammalian epidermal development by using PSMA7 conditional knockout model

Dr Qianting Zhang, National Natural Science Funds of China - Young Scientists Fund   

Study on the molecular mechanism of CDC-42 sensing the damage of nematode epidermal cell membrane

Dr Jungxiu Xu, National Natural Science Funds of China - Young Scientists Fund   

Tissue Engineering and Regeneration of the Musculoskeletal System

Prof Hongwei Ouyang, National Natural Science Funds of China - Innovative Research Group Project

Systematic quantitative analysis and prediction on dominance and recessivity of genetic mutations

Dr Xianghua Li, National Natural Science Funds of China - Young Scientists Fund 

Study the function and mechanism of CD8 T cells in EAE disease based on TCR-sequencing

Dr Yadan Bai, National Natural Science Funds of China - Young Scientists Fund 

Study on the molecular dynamic mechanism of SYX-2 in regulating epidermal membrane repair in C. elegans

Dr Xinan Meng, National Natural Science Funds of China - Young Scientists Fund 

Consequences of MALTl mutation for B cell tolerance

Dr James Qun Wang, National Natural Science Funds of China - Young Scientists Fund 

Understand the function and mechanism of LTR5 Hs retrotransposon in human primordial germ cell development

Dr Wanlu Liu, National Natural Science Funds of China - General Project

Investigation of the Mechanism of SMAD4 regulating 3D Chromatin Architecture to Suppress Lung Cancer Development

Dr Jian Liu, National Natural Science Funds of China - General Project

Identification and characterization of a novel epithelial–mesenchymal intermediate (EMI) subpopulation that marks tumor-propagating stem cells

Dr Wei Guo, National Natural Science Funds of China - General Project

The mechanism study of spontaneous calcium oscillation in astrocyte process growth via regulating endosome/lysosome translocation

Dr Hong Zhi, National Natural Science Funds of China - General Project                               

Design of Stimuli-Responsive Silk–Elastin‐Like Protein Hydrogels for Tissue Regeneration.

Dr Huang Wenwen, National Natural Science Funds of China - Youth Scientists Fund                                

MSCs cell sheets combined with biomimetic “molecular glue” for the repair of partial-thickness cartilage defect

Dr Wang Xiaozhao, National Natural Science Funds of China - Youth Scientists Fund                                

High-Resolution Dissection and Precise Regulation of Chondrocyte Temporal Phenotypes during Cell Expansion

Dr Chen Yishan, National Natural Science Funds of China -Youth Scientists Fund                                         

Molecular mechanism of MZIP2-interacting protein in regulating DNA homologous recombination

Dr Zhang Qianting, National Natural Science Funds of Zhejiang Province - Exploration projects                   

High-resolution dissection of the time-lapse changes of functional phenotypes in chondrocyte expansion

Dr Chen Yishan, China Postdoctoral Science Foundation - General funding (second class)                               

Study on the characteristics of Pseudomonas phage for treatment

Dr Prasanth Manohar, Department of human resources and social security of Zhejiang Province -Excellent funding                                 

Study on the mechanism of PTEN regulating hematopoietic stem cells    

Dr Wang Xiaoling, China Postdoctoral Science Foundation - Special subsidy (before the station)                    

Multistimuli-responsive silk-elastin-like protein hydrogels for dynamic biomaterials

Dr Huang Wenwen, Zhejiang University -Cornell University International Cooperation seed fund -             

International Cooperation                        

New coronavirus (2019 nCoV) pneumonia emergency research project: Molecular, clinical and socio-epidemiological analyses of 2019 nCoV for the development of novel diagnostic and therapeutic tools.

Prof Susan Welburn, Fund for prevention and control of viral infectious diseases - Emergency Research Project

The mechanisms of autoimmune diseases caused by CTLA-4 mutation.

Prof. Linrong Lu, National Natural Science Foundation-Key Progam

Characterization and targeted inhibition of non-canonical NOTCH1 signaling in therapeutic resistance.

Dr. Wei Guo, National Natural Science Foundation-General Progam

Analysis of proteome thermal stability during metabolic rewiring.

Dr. Mikael Bjorklund, National Natural Science Foundation-General Progam

The mechanism study of JAK/STAT5 regulating mammary gland development via super-enhancer driven non-coding gene cluster Bvht-miR145-Carmn.

Dr. Chaochen Wang, National Natural Science Foundation-General Progam

Study of Cartilage ECM-like Molecular Paints for Joint Surface Cartilage Repair.

Dr. Wei Wei, National Natural Science Foundation-Youth Scientists Fund

Study on the role of MINK1 in virus replication.

Dr. Mingxu Zhang, National Natural Science Foundation-Youth Scientists Fund

Elucidating the multi-functional role of Membrane-embedded molecular motors.

Dr. Belinda Wei-Ching Loh, China Postdoctoral Science Foundation

Study of molecular self-assembling hydrogels for articular surface repair.

Dr. Wei Wei, China Postdoctoral Science Foundation

Role of transposon SVA element in human naïve fetal stem cells and its regulatory mechanism  

Dr Liu Wanlu, National Natural Science Funds of Zhejiang Province - Exploration projects                                 

Rapid construction of functional osteochondral bionic structure by 3D light printing

Dr Wang Xiaozhao, China Postdoctoral Science Foundation- General funding (second class)   

Effect and mechanism of SGK1 inhibitor in inflammatory bowel disease

Dr Zhang Mingxu, China Postdoctoral Science Foundation - General funding (second class)

The study of Biological Effects & Risks of Nano-Cluster Materials.

Prof. Linrong Lu, National Key Research and Development Project,

High-definition analysis and precise regeneration of complex connection structures of skeletal systems.

Prof. Hongwei Ouyang, National Natural Science Foundation-Key Progam

Role of nuclear receptor COUP-TFII in colorectal tumorigenesis

Dr. Xin Xie, Zhejiang Natural Science Foundation Program- Key Program

Study of joint-paints based on chondroitin sulfate for superficial cartilage defects of osteoarthritis repair.

Dr. Wei Wei, Zhejiang Natural Science Foundation Program- General Program

Packaging and transfer of exogenous mitochondrial DNA via extracellular vesicles delays stem cell senescence.

Dr. Xudong Yao,Zhejiang Natural Science Foundation Program- General Program

Repair mechanism and anti-aging application of stem cell derived mitochondria transplantation   

Dr Yao Xudong, China Postdoctoral Science Foundation - General funding (second class)   

Automatic and scale culture amplification system of stem cells in vitro.

Prof. Hongwei Ouyang, National Key Research and Development Program

Subtype identification and regeneration of degenerative osteoarthritis.

Prof. Hongwei Ouyang,National Natural Science Foundation-Key Progam

The role of protein phosphatase PP2A in Th17 differentiation and inflammatory autoimmune diseases.

Prof. Linrong Lu,National Natural Science Foundation-General Progam